At the time of the study, the QResearch database contained the anonymised longitudinal health records of more than 12 million patients from more than 600 general practices across the United Kingdom, which record data using the Egton Medical Information Systems (EMIS) medical records computer system. Recorded information includes patients’ characteristics, clinical diagnoses, symptoms, and prescribed drugs.The cohort included patients with a first computer recorded diagnosis of depression between the ages of 20 and 64 years at the time of diagnosis, from 1 January 2000 to 31 July 2011, as described previously.22 We identified patients with a diagnosis of depression by using diagnostic Read codes used in previous studies.10 23 24 Read codes are the clinical codes used in general practice in the United Kingdom. Patients were eligible for inclusion if their diagnosis of depression occurred at least 12 months after their registration with a study practice and the installation date of their practice’s EMIS computer system.
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